Meropenem Trihydrate USP

Trade name:  Merom injection

GENERIC NAME: Meropenem Trihydrate USP

THERAPEUTIC CLASS: Antibacterial (Carbapenem)

DESCRIPTION

Merom is an ultra-broad spectrum injectable antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam antibiotic and belongs to the subgroup of carbapenem.

FORMULATION

Merom 500mg IV Injection: Each vial contains Meropenem trihydrate equivalent to Meropenem 500mg.

Merom 1gm IV Injection: Each vial contains Meropenem trihydrate equivalent to Meropenem 1gm.

MECHANISM OF ACTION

Merom (Meropenem) exerts its bactericidal action by interfering with bacterial cell wall synthesis. Thus it penetrates into bacterial cells, its high level of stability to all _-lactamases and its marked affinity for the Penicillin Binding Proteins (PBPs) explain in the potent bactericidal activity of meropenem against a broad spectrum of aerobic and anaerobic and anaerobic bacteria.

PBPs involoved in the final stages of the synthesis of peptidoglycan

                                 |--------------------------                        Merom -------------|

            To growth, cell division and maintaining the cellular structure in bacteria

Inhibition of PBPs leads to irregularities in cell wall structure such as elongation

Lesions, loss of selective permeability, and eventual cell death and lysis.

                                 |_______________________________________________

MICROBIOLOGY

Merom is effective against aerobic & facultative gram-positive microorganisms such as – Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumonia, Streptococcus pyogenes, Staphy lococcus epidermidis etc.

Merom also covers most aerobic & facultative gram-positive microorganisms such as-Escherichia cole, Heamophilus influenzae, Klebsiella pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Klebsiella oxytoca etc.

Merom is also effective against most anaerobic microorganisms such as-Bacteraoides fragilis, Bacteraoides thetaiotaomicron, Peptostreptococcus species, Bacteroides vulgatus, Clostridium difficile etc.

CLINICAL INDICATIONS

·        Meningitis

·        Febrile neutropenia

·        Urinsry tract infections

·        Intra abdominal infections

·        Lower respiratory tract infections: Pneumonia, chronic bronchition of chronic        bronchitis.

·        Septicemia

·        Gynecological & obstetric infections

·        Peneumonia & nososcomial pneumonia

·        Skin & skin structure infections

·        Pulmonary infection

·         

DOSAGE & ADMINISTRATION

Adults:

The recommended daily doses are based depending upon the severity of the infections & condition of the patients. Peneumonia, UTI, gynaecological infections such as endometritis, skin & skin structure infections-500mg i.v every 8 houre. Noscomial Pneumonias, peritonitis, presumed infections in neutropenic patients & septicaemia- 1gm i.v every 8 hours. Meningitis-2gm every 8 hours.

Children (3 months to 12 years):

10-20mg/kg i.v every m8 hours depending on the type & severity of infections, susceptibility of the pathogens & condition of the patients. Children over 50kg body weight- adult dosage. Meningitis-40mg/kg every 8 hours.

 SIDE EFFECT

·        Stomach upset & pain, diarrhea,

·        Indigestion, constipation

·        Dry mouth, Headache, seizures

·        Fatigue and dizziness etc.

DRUG INTERACTIONS

-Probenecid: It may increases the levelos of meropenem in the blood.

-Sodium valporate: may7 reduce the serum valporic acid level.

CONTRAINDICATIONS

Merom is contraindicated in patients with known allergy to this active ingredient.

BRAND INFORMATION

Preparation	Pack size	MRP(in Tk.)
Merom 500mg IV injection	1 vial	950
Merom 1gm IV injection	1vial	1800

PRODUCT POSITIONING                                     Success Rate 

·        First line antibiotic for ICU patients                                        

·        Intra abdominal infections (IAI)                             100%

·        Febrile neutropenia                                                  55% (vs 43% for  ceftazidime)

·        Urinary tract infections                                           100%

·        Pneumonias & Nosocomial Pneumonias                100%

·        Bacterial septicemia                                                100%

·        Meningitis                                                                 99%

·        Pulmonary infections                                              100%

·        Cystic fibrosis                                                         100%

TARGET DOCTORS

• ICU consultant/Incharge
• Anesthesiologists
•  Oncologist
• Medicine Specialist
• Gynecologist
• ENT specialist
• Gastroenterologist

COMPETITIVE PRICE

Competitor	Brand name	Pack size	MRP/500mg	MRP/1gm
Renata	Meropen	1 vial	995	1950
Incepta	I-Penam	1 vial	995	1950
Popular	Merobac	1 vial	950	1850
Square	Specbac	1 vial	995	1950
ACI	Meronem	1 vial	950	2545.85
Techno Drugs	Merom	1 vial	950	1800