Cefixime Injection

Trade name:  loxime injection

GENERIC NAME: Cefixime BP

THERAPEUTIC CLASS: Antibacterial (3^rd generation Cephalosporin)

DESCRIPTION: Cefixime BP is a third-generation cephalosporin antibiotic. Like other   third-generation cephalosporins, it has broad spectrum activity against Gram positive and gram negative bacteria.

1^st generation cephalosporins: First generation cephalosporins are moderate spectrum agents, with a spectrum of activity that includes penecillinase-producing, methicillin-susceptible staphylococci and streptococci, though they are not the drugs of choice for such infactions. E.g. Cefadroxi (Sefadol), Cephradine (Dolocef), ceftezole etc.

2nd generation cephalosporins : The second  generation cephalosporins have grater Gram-negative spectrum while retaining some activity against Gram-posotive cocci. They are also more resistant to beta-lactamase. e.g. Cefaclor (Dolocef), Cefuroxime, Cefonicid etc.

3^rd generation cephalosporins: Third generation cephalosporins have a board spectrum of activity and further increased activity against Gram-negative organisms. e.g. Ceftriaxone (cefixon), Cefixime (Loxim), Cefpodoxime etc.

4th generation cephalosporins: Fourth generation cephalosporins are extended-spectrum agents with similar activity against Gram-positive organisms as first-generation cephalosporins & more active against Gram-negative organism e.g. Cefipime, Cefpirome etc.

FORMULATION

Loxim 200mg tablet: Each tablet contains Cefixime Trihydrate BP equivalent to Cefixime 200 mg.

Loxim 400mg tablet: Each tablet contains Cefixime Trihydrate BP equivalent to Cefixime 400 mg.

Loxim  100mg/5ml dry syrup (50ml): After reconstitution, each 5ml contains Cefixime Trihydrate BP epuivalent to cefixime 100mg.

MECHANISM OF ACTION

Loxim belongs to a group of antibiotics called the cephalosporin. It kills bacteria by interfering with transpeptidase enzyme which is responsible for the synthesis of bacterial cell wall, peptidoglycan. The bacteria therefore break up and die

   

                          Transpeptidation

                                     |     Transpeptidation       <     -        Cefixon

                                        

                             Peptidoglycan

                                     |

                Stability & rigidity of bacterial cell wall

MICROBIOLOGY

Loxim is effective grampositive microoganisma such as   -   Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae etc.

Loxim is effective grampositive microoganisma such as   -   Heamophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Salmonella species, Shigella species etc.

CLINICAL INDICATIONS

Infections caused by pathogens sensitive to Cefixime, e.g.:

·        Upper respiratory tract infections: Pharyngitis, tonsillitis.

·        Lower respiratory tract infections: Pneumonia, chronic bronchitis, acute exacerbation of chronic bronchitis

·        Urinary tract infections

·        Ear, lung, throat infections

·        Uncomplicated gonorrhoea.

DOSAGE & ADMINISTRATION

Adults: The recommended dose of Loxim is 400mg daily. This may be given as a 400 mg tablet daily or as 200mg tablet every 12 hours.

For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400mg is recommended.

Children: The recommended dose is 8 mg /kg/day of the suspension.

This may be administered as a single daily dose or may be given in two divided doses, as 4mg/kg every 12 hours 7 to14 days according to the severity of infection or for children of  age:

1/2-1 year                          : 3.75 ml or mg

1-4year                              : 5 ml or 100mg

5-10year                            : 10 ml or 200mg

11-12year                          : 15 ml or 300mg

Above12year                     : Adult dose

SIDE EFFECTS

·        Upset stomach, diarrhea, vomiting, mild skin rash, itching

·        Headache, hives

·        Difficulty breathing or swallowing

·        Wheezing

·        Vaginal infection etc.

DRUG INTERACTIONS

Oral contraceptive: Cephalosporins such as cefixime may reduce the effectiveness of the combined oral contraceptive pill.

Probenecid: The removal of cefixime from the body may be slowed if given with probenecid.

CONTRAINDICATIONS

Loxim is contraindicated in patients with know allergy to the cephalosporin class of antibiotics.

BRAND INFORMATION

Preparation	Pack size	MRP/box	MRP/unit
Loxim 200mg tablet	1*10	250	25
Loxim 400mg tablet	1*6	270	45
Loxim 100mg/5ml dry syrup	50ml	190	190

 

PRODUCT POSTING

Shows higher success rate in respiratory tract infections.

•    Pharyngitis                      94%
•    Otitis media                    96%
•    Pneumonia                     100%
•    Bronchitis                        98%

Provides excellent therapy in gonococcal infection (caused by N. gonorrhoeae)

•    Eradication rate               98%

Ensures effect treatment success in UTI’s

•      Cure rate                          99%

Offers outstanding success rate in multidrug resistant fever in children.

• Clinical response            100%

TAARGET DOCTORS

• Medicine Specialists
• Urologists
• Gynecologists
• Pulmonologists
• ENT specialists
• GP’s
• DGP’s

COMPETITIVE PRICE

Loxim 200mg tablet
Competitor	Brand name	Pack size	MRP/box	MRP/UNIT
Opsonin	Ceftid	6’S	270	45
Renata	Orcef	8’s	270	33.75
Popular	Zemicef	8’s	200	25
Techno Drugs	Loxim	12’s	300	25

Loxim 100mg/5ml dry syrup

Competitor	Brand name	Pack size	MRP/box	MRP/UNIT
Opsonin	Ceftid	50ml	275	275
Silva	Supraxim	50ml	250	250
Orion	Truso	50ml	160	160
Techno Drugs	Loxim	50m	190	190

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