Trade name: loxime injection
GENERIC NAME: Cefixime BP
THERAPEUTIC CLASS: Antibacterial (3rd generation Cephalosporin)
DESCRIPTION: Cefixime BP is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and gram negative bacteria.
1st generation cephalosporins: First generation cephalosporins are moderate spectrum agents, with a spectrum of activity that includes penecillinase-producing, methicillin-susceptible staphylococci and streptococci, though they are not the drugs of choice for such infactions. E.g. Cefadroxi (Sefadol), Cephradine (Dolocef), ceftezole etc.
2nd generation cephalosporins : The second generation cephalosporins have grater Gram-negative spectrum while retaining some activity against Gram-posotive cocci. They are also more resistant to beta-lactamase. e.g. Cefaclor (Dolocef), Cefuroxime, Cefonicid etc.
3rd generation cephalosporins: Third generation cephalosporins have a board spectrum of activity and further increased activity against Gram-negative organisms. e.g. Ceftriaxone (cefixon), Cefixime (Loxim), Cefpodoxime etc.
4th generation cephalosporins: Fourth generation cephalosporins are extended-spectrum agents with similar activity against Gram-positive organisms as first-generation cephalosporins & more active against Gram-negative organism e.g. Cefipime, Cefpirome etc.
FORMULATION
Loxim 200mg tablet: Each tablet contains Cefixime Trihydrate BP equivalent to Cefixime 200 mg.
Loxim 400mg tablet: Each tablet contains Cefixime Trihydrate BP equivalent to Cefixime 400 mg.
Loxim 100mg/5ml dry syrup (50ml): After reconstitution, each 5ml contains Cefixime Trihydrate BP epuivalent to cefixime 100mg.
MECHANISM OF ACTION
Loxim belongs to a group of antibiotics called the cephalosporin. It kills bacteria by interfering with transpeptidase enzyme which is responsible for the synthesis of bacterial cell wall, peptidoglycan. The bacteria therefore break up and die
Transpeptidation
| Transpeptidation < - Cefixon
Peptidoglycan
|
Stability & rigidity of bacterial cell wall
MICROBIOLOGY
Loxim is effective grampositive microoganisma such as - Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae etc.
Loxim is effective grampositive microoganisma such as - Heamophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Salmonella species, Shigella species etc.
CLINICAL INDICATIONS
Infections caused by pathogens sensitive to Cefixime, e.g.:
· Upper respiratory tract infections: Pharyngitis, tonsillitis.
· Lower respiratory tract infections: Pneumonia, chronic bronchitis, acute exacerbation of chronic bronchitis
· Urinary tract infections
· Ear, lung, throat infections
· Uncomplicated gonorrhoea.
DOSAGE & ADMINISTRATION
Adults: The recommended dose of Loxim is 400mg daily. This may be given as a 400 mg tablet daily or as 200mg tablet every 12 hours.
For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400mg is recommended.
Children: The recommended dose is 8 mg /kg/day of the suspension.
This may be administered as a single daily dose or may be given in two divided doses, as 4mg/kg every 12 hours 7 to14 days according to the severity of infection or for children of age:
1/2-1 year : 3.75 ml or mg
1-4year : 5 ml or 100mg
5-10year : 10 ml or 200mg
11-12year : 15 ml or 300mg
Above12year : Adult dose
SIDE EFFECTS
· Upset stomach, diarrhea, vomiting, mild skin rash, itching
· Headache, hives
· Difficulty breathing or swallowing
· Wheezing
· Vaginal infection etc.
DRUG INTERACTIONS
Oral contraceptive: Cephalosporins such as cefixime may reduce the effectiveness of the combined oral contraceptive pill.
Probenecid: The removal of cefixime from the body may be slowed if given with probenecid.
CONTRAINDICATIONS
Loxim is contraindicated in patients with know allergy to the cephalosporin class of antibiotics.
BRAND INFORMATION
Preparation
|
Pack size
|
MRP/box
|
MRP/unit
|
Loxim 200mg tablet
|
1*10
|
250
|
25
|
Loxim 400mg tablet
|
1*6
|
270
|
45
|
Loxim 100mg/5ml dry syrup
|
50ml
|
190
|
190
|
PRODUCT POSTING
Shows higher success rate in respiratory tract infections.
- Pharyngitis 94%
- Otitis media 96%
- Pneumonia 100%
- Bronchitis 98%
Provides excellent therapy in gonococcal infection (caused by N. gonorrhoeae)
- Eradication rate 98%
Ensures effect treatment success in UTI’s
- Cure rate 99%
Offers outstanding success rate in multidrug resistant fever in children.
- Clinical response 100%
TAARGET DOCTORS
- Medicine Specialists
- Urologists
- Gynecologists
- Pulmonologists
- ENT specialists
- GP’s
- DGP’s
COMPETITIVE PRICE
Loxim 200mg tablet
| ||||
Competitor
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Brand name
|
Pack size
|
MRP/box
|
MRP/UNIT
|
Opsonin
|
Ceftid
|
6’S
|
270
|
45
|
Renata
|
Orcef
|
8’s
|
270
|
33.75
|
Popular
|
Zemicef
|
8’s
|
200
|
25
|
Techno Drugs
|
Loxim
|
12’s
|
300
|
25
|
Loxim 100mg/5ml dry syrup
Competitor
|
Brand name
|
Pack size
|
MRP/box
|
MRP/UNIT
|
Opsonin
|
Ceftid
|
50ml
|
275
|
275
|
Silva
|
Supraxim
|
50ml
|
250
|
250
|
Orion
|
Truso
|
50ml
|
160
|
160
|
Techno Drugs
|
Loxim
|
50m
|
190
|
190
|
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